In Summary

  • The clinic and patients involved were not named in the study, which was co-authored by Thomas Albini, associate professor of clinical ophthalmology at the University of Miami.
  • Two of the patients sought treatment at the university's hospital for the complications they suffered.
  • "There's a lot of hope for stem cells, and these types of clinics appeal to patients desperate for care who hope that stem cells are going to be the answer," said Albini.

An unproven stem cell therapy that involves extracting a patient's fat tissue and injecting it into the eyes has caused three US women to go blind,  a report said Wednesday.

The women, aged between 72 and 88, were treated in Florida in 2015 for a progressive eye disease called macular degeneration, said the report in the New England Journal of Medicine.

They thought they were enrolling in a legitimate clinical trial, having found it under the title: "Study to assess the safety and effects of cells injected intravitreal in dry macular degeneration" on ClinicalTrials.gov, the US government website for such research.

However, they immediately suffered complications, including retinal detachment and haemorrhage, which caused total loss of eyesight.

The clinic and patients involved were not named in the study, which was co-authored by Thomas Albini, associate professor of clinical ophthalmology at the University of Miami.

Two of the patients sought treatment at the university's hospital for the complications they suffered.

"There's a lot of hope for stem cells, and these types of clinics appeal to patients desperate for care who hope that stem cells are going to be the answer," said Albini.

"But in this case these women participated in a clinical enterprise that was off-the-charts dangerous."

RED FLAGS

The procedure claimed to use adipose-derived stem cells to restore vision.

Patients had fat cells removed from their abdomens. This fat tissue was processed with enzymes in order to get stem cells, which would be mixed with platelet-dense plasma and injected into their eyes.

Albini said the complications could have been caused by contamination during the mixing process, or the stem cells, once injected into the eye, could have changed into a type of cell that led to scarring.

Whatever happened, experts said there was no evidence to suggest the procedure would have helped restore vision, since so little study has been done on whether adipose-derived stem cells can mature into the kinds of retinal cells that are involved in macular degeneration.

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