"I don't believe what I'm seeing right now. I knew Kaweesi well and met with him about a week and a half ago to discuss tarmacking the road he was shot on."
Kaweesi rose to prominence as he spearheaded the police response to widespread opposition party protests following a controversial 2011 presidential election.
After a stint as commander of Kampala Metropolitan Police, he was appointed director of operations and then head of human resources before assuming the role of main police spokesman in August 2016.
He appeared regularly on television talk shows, his most recent appearance being Thursday night on NTV, one of the major private channels in the country.
Kaweesi's killing resembles the assassinations of other high profile legal and military personnel.
In March 2015, Joan Kagezi, a senior public prosecutor, was shot in the street and the assailant escaped with an accomplice on a motorcycle.
In November last year Ugandan army officer, major Sulaiman Kiggundu, former Allied Democratic Forces rebel, was shot in his car by gunmen travelling on two motorcycles.
Both crimes remain unsolved.
President Museveni condemned the killing of Kaweesi by gunmen he described as thugs riding on motorcycles.
As a consequence of these repeated murders in the city and other towns, the President has directed the immediate installation of cameras in all major towns of Uganda and along the highways.
Mr Museveni further noted that the security personnel and all citizens should be vigilant and on the lookout for these “thugs who have made it a habit to use motorcycles to kill people.”
“Remember the incidents of Joan Kagezi, Major Kiggundu (Mohammad) and a number of Sheikhs; they were killed in the same manner," he said.
" If you notice such characters and especially if they are trailing a person with armed guards, you should take prompt action and challenge them,” added Mr Museveni.