The UN refugee agency and the White Nile police chief confirmed there was unrest at the camp.
The police chief said senior state officials were on their way to the camp to investigate the incident.
About 410,000 South Sudanese refugees have arrived in Sudan since a brutal civil war erupted in their country in December 2013.
Fire and violence broke out Thursday at the biggest South Sudanese refugee camp in Sudan, a security official said
The scale and cause of the violence at the Al Waral Camp in Sudan's Southern White Nile was not immediately clear, but local police officers and government officials rushed to the camp to investigate the incident.
The UN refugee agency and the White Nile police chief confirmed there was unrest at the camp where some 50,000 South Sudanese refugees live.
"We got reports that there was disturbance and fire in Khor Al Waral Camp of South Sudanese refugees," White Nile Police Chief General Eltieb Gourashi told AFP.