- Sharapova was wearing a bandage on her left thigh.
- She pulled out of her contest against Croatian veteran Mirjana Lucic-Baroni while leading 4-6, 6-3, 2-1 to round out a miserable day for the five-time Grand Slam champion.
Maria Sharapova retired with injury in her second-round match in Rome, just hours after she was denied a wild card for the French Open, while defending champion Andy Murray crashed to a heavy defeat in his opener against Fabio Fognini on Tuesday.
Sharapova, who was wearing a bandage on her left thigh, pulled out of her contest against Croatian veteran Mirjana Lucic-Baroni while leading 4-6, 6-3, 2-1 to round out a miserable day for the five-time Grand Slam champion.
"I apologise for having to withdraw from my match with a left thigh injury," Sharapova said in a statement. "I will be getting all the necessary examinations to make sure it is not serious."
Defeat in Rome meant the 30-year-old also missed out on a chance to qualify for the main draw at Wimbledon, which she could have achieved by reaching the semi-finals in the Italian capital.
World number one Murray's Rome Masters title defence then ended worryingly early as he was comfortably beaten 6-2, 6-4 by local favourite Fognini after a first-round bye.
Murray limped to another premature exit with flamboyant shot-maker Fognini bossing the Scottish top seed around at will and breaking him four times.
Murray succumbed to the Italian in just over 90 minutes and has major work to do before the start of Roland Garros in less than a fortnight.
He hasn't reached the quarter-final of a major event in 2017, with the loss to Fognini his seventh of the season.
"I'm sure there were a lot of things I could have done better. He obviously he started the match extremely well," said Murray.
"I wasn't creating enough chances on my own. The only chance I really got was when he was making errors.
"I definitely felt a little bit better... but still not close to where I would like to be, obviously."