Roma, only four points off the pace, travel to Chievo for Saturday's early game looking to keep the pressure on and buoyed by the return of Dutch midfielder Kevin Strootman and trophy-chasing striker Edin Dzeko.
Strootman returns from a two-game ban, for simulation, while Dzeko, who leads the chase for the top scorer's 'Capocannoniere' award on 27 goals — two ahead of Andrea Belotti (Torino) and Dries Mertens (Napoli) — trained this week following his recovery from a calf injury.
Napoli, in third at one point behind Roma, host Fiorentina in Saturday's late fixture a week after a 5-0 rout at Torino.
Fiorentina, in seventh and only one point behind AC Milan and a Europa League place, are missing Spanish midfielder Borja Valero through suspension.
Lazio have already qualified for the Europe League but welcome embattled Inter Milan looking to make amends for their midweek Cup loss with victory in their final home game of the season.
Less than two weeks after Stefano Pioli was sacked by Inter, youth team coach Stefano Vecchi is at the helm again but should leave injury-hit captain Mauro Icardi on the bench in place of Eder.
At the San Siro last week, the entire 'Curva Nord' section which houses Inter's 'ultras' left the stadium after 25 minutes of a shock 2-1 loss to Sassuolo "to have lunch" — according to a banner they left behind — to protest Inter's dire season.
Sitting four points behind city rivals Milan, the Nerazzurri need to beat Lazio to have any chance of qualifying for the Europa League.
Chievo v Roma (7pm), Napoli v Fiorentina (9.45pm)
Empoli v Atalanta, Genoa v Torino, Juventus v Crotone, AC Milan v Bologna, Sassuolo v Cagliari, Udinese v Sampdoria (all 4pm), Lazio v Inter Milan (9.45pm) Monday Pescara v Palermo (9.45pm)