- Exeter's Henry Slade starts at inside centre, with George Kruis and Courtney Lawes the second-row duo.
- On the wings, Jones has opted for Elliot Daly and Anthony Watson.
England coach Eddie Jones left out both inside centre Owen Farrell and lock Maro Itoje when he named his side Thursday for this weekend's November international opener against Argentina at Twickenham.
The Australian had previously indicated he would rest players who had been involved in the British and Irish Lions gruelling 1-1 drawn series in New Zealand earlier this year and the former Wallaby and Japan boss backed up those words by leaving Itoje and Farrell out of his matchday 23 for Saturday's fixture with the Pumas.
Instead Exeter's Henry Slade starts at inside centre, with George Kruis and Courtney Lawes the second-row duo.
On the wings, Jones has opted for Elliot Daly and Anthony Watson.
Daly was set to miss England's opening two November Tests against Argentina and Australia with knee ligament damage but has made a quicker than expected recovery while Leicester flyer Jonny May has been ruled out from facing the Pumas with a hamstring strain.
Sam Underhill starts at openside flanker, with Tom Curry among a list of replacements that includes lock Joe Launchbury.
Jamie George started all three Tests for the Lions but once again the hooker is on the England bench behind captain Dylan Hartley.