- Football authorities have been accused of dragging their feet on the matter since former England player Jeff Astle died in 2002, with the coroner citing industrial disease as the cause of death.
- European governing body Uefa earlier this year commissioned two separate studies to look at heading in youth football, showing the issue is on the agenda.
Does heading a football give you dementia?
That's the question neuropathologist Willie Stewart is attempting to answer by comparing the health of thousands of former footballers with non-players.
Football authorities have been accused of dragging their feet on the matter since former England player Jeff Astle died in 2002, with the coroner citing industrial disease as the cause of death.
Ex-England and Newcastle captain Alan Shearer, famed for his prowess in the air, has helped raise the profile of the issue by speaking of his dementia fears after years of heading balls.
The man tasked with investigating whether there is a direct link is Stewart, whose research team is comparing the medical histories of 10,000 former professional footballers with 30,000 members of the general population.
The study, "Football's Influence on Lifelong Health and Dementia Risk", is funded by the Football Association and the Professional Footballers' Association, with the aim of gathering hard evidence on an emotive subject.
It was Stewart who in 2014 said that Astle had died aged 59 from chronic traumatic encephalopathy (CTE) stemming from head injuries after examining the former player's brain. The condition is normally associated with boxers.
But he is cautious in his approach and said delving into big data is crucial because the issue is currently clouded by anecdote and speculation.
He cites the example of three members of England's 1966 World Cup-winning team who developed Alzheimer's disease - Martin Peters, 74, and Ray Wilson and Nobby Stiles, both deceased.
"The problem is that bad science comes from anecdotes and they are all we have got," he told AFP at Queen Elizabeth University Hospital in Glasgow.
"Anecdotes are quite persuasive as quite a lot of the 1966 winning team have dementia and other football teams have been brought forward with high rates of dementia but we don't fully understand."
Stewart says it is not a simple matter of cause and effect.
"One has to know whether for instance the other teams in the 1966 World Cup, do they have similar levels of dementia?" he said.