- City's bid for an unprecedented quadruple is over and now the question is whether they can recover in time to overhaul Liverpool in the Premier League title race.
- Spurs could ruin that City dream as well when they return to the Etihad Stadium in the league on Saturday.
Tottenham have earned a Champions League semi-final clash against Ajax, beating Manchester City on away goals after a 4-3 defeat secured a 4-4 aggregate score in one of the games of the season on Wednesday.
Here AFP Sport looks at three things we learned from a sensational quarter-final second leg:
After a series of frustrating defeats when the stakes were at their highest, Mauricio Pochettino's Tottenham finally came through on the big occasion.
Falling short in FA Cup semi-finals, Champions League knockout games and Premier League title battles had tarnished Pochettino's otherwise impeccable credentials as one of the brightest young managers in Europe.
But, playing without injured star striker Harry Kane, Pochettino inspired a tour de force performance from Tottenham.
Pochettino is yet to win his first major trophy, but he out-witted City boss Pep Guardiola, who has won every prize the game can offer.
Tottenham were aided by two huge VAR decisions that allowed to them to score the decisive third goal when Fernando Llorente bundled in off a combination of his arm and hip - and then escape what would have been a Raheem Sterling last-gasp winner as offside was given against Sergio Aguero.
But luck wasn't the reason for Pochettino's success as he leads Tottenham in the Champions League semi-finals for the first time despite not buying a single player in the last two transfer windows due to the restraints from the move to their new stadium.
Tottenham are in the last four of a European competition for the first time since the 1984 Uefa Cup because Pochettino and no wonder Tottenham's jubilant fans chanted Pochettino's name loudly as he danced with his players on the pitch at full-time.
Pep Guardiola held his head in his hands when Ilkay Gundogan's close-range effort ballooned over the bar in the closing moments, the Manchester City manager's angst at his latest Champions League failure clear for all to see.
Guardiola is rightly regarded as the best manager of his generation after trophy-laden spells with Barcelona, Bayern Munich and now City.